Neurobiology of Disease Cortical Oscillatory Activity Is Critical for Working Memory as Revealed by Deficits in Early-Onset Schizophrenia
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چکیده
Corinna Haenschel,1,2,3 Robert A. Bittner,1,2,4 James Waltz,5 Fabian Haertling,6 Michael Wibral,4 Wolf Singer,2 David E. J. Linden,3 and Eugenio Rodriguez2,7 1Laboratory for Neurophysiology and Neuroimaging, Department of Psychiatry, Johann Wolfgang Goethe University, 60590 Frankfurt, Germany, 2Max Planck Institute for Brain Research, 60528 Frankfurt, Germany, 3School of Psychology, Bangor University, Gwynedd LL57 2AS, United Kingdom, 4Brain Imaging Center, 60528 Frankfurt, Germany, 5University of Maryland School of Medicine, Baltimore, Maryland 21228, 6Department of Child and Adolescent Psychiatry, Johann Wolfgang Goethe University, 60528 Frankfurt, Germany, and 7Pontificia Universidad Católica de Chile, Escuela de Psicología, 7820436 Macul, Santiago, Chile
منابع مشابه
Cortical oscillatory activity is critical for working memory as revealed by deficits in early-onset schizophrenia.
Impairments in working memory (WM) are a core cognitive deficit in schizophrenia. Neurophysiological models suggest that deficits during WM maintenance in schizophrenia may be explained by abnormalities in the GABAergic system, which will lead to deficits in high-frequency oscillations. However, it is not yet clear which of the three WM phases (encoding, maintenance, retrieval) are affected by ...
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تاریخ انتشار 2009